Your doctor will monitor your symptoms carefully and will probably order certain tests to check your body's response to nabumetone. Keep all appointments with your doctor and the laboratory. If you experience any of the following symptoms, stop taking nabumetone and call your doctor: stomach pain, heartburn, vomit that is bloody or looks like coffee grounds, blood in the stool, or black and tarry stools. Also tell your doctor if you have or have ever had ulcers, bleeding in your stomach or intestines, or other bleeding disorders. Tell your doctor if you take any of the following medications: anticoagulants ('blood thinners') such as warfarin (Coumadin, Jantoven) aspirin other NSAIDs such as ibuprofen (Advil, Motrin) and naproxen (Aleve, Naprosyn) oral steroids such as dexamethasone, methylprednisolone (Medrol), and prednisone (Rayos) selective serotonin reuptake inhibitors (SSRIs) such as citalopram (Celexa), fluoxetine (Prozac, Sarafem, Selfemra, in Symbyax), fluvoxamine (Luvox), paroxetine (Brisdelle, Paxil, Pexeva), and sertraline (Zoloft) or serotonin norepinephrine reuptake inhibitors (SNRIs) such as desvenlafaxine (Khedezla, Pristiq), duloxetine (Cymbalta), and venlafaxine (Effexor XR). The risk may be higher for people who take NSAIDs for a long time, are older in age, have poor health, or who drink large amounts of alcohol while taking nabumetone. These problems may develop at any time during treatment, may happen without warning symptoms, and may cause death. NSAIDs such as nabumetone may cause ulcers, bleeding, or holes in the stomach or intestine. If you will be undergoing a coronary artery bypass graft (CABG a type of heart surgery), you should not take nabumetone right before or right after the surgery.
Get emergency medical help right away if you experience any of the following symptoms: chest pain, shortness of breath, weakness in one part or side of the body, or slurred speech. Tell your doctor if you or anyone in your family has or has ever had heart disease, a heart attack, or a stroke, if you smoke, and if you have or have ever had high cholesterol, high blood pressure, or diabetes.
Do not take an NSAID such as nabumetone if you have recently had a heart attack, unless directed to do so by your doctor. This risk may be higher for people who take NSAIDs for a long time. These events may happen without warning and may cause death.
July 9, 2015.People who take nonsteroidal anti-inflammatory drugs (NSAIDs) (other than aspirin) such as nabumetone may have a higher risk of having a heart attack or a stroke than people who do not take these medications. FDA Drug Safety Communication: FDA Strengthens Warning That Non-aspirin Nonsteroidal Anti-inflammatory Drugs (NSAIDs) Can Cause Heart Attacks or Strokes. Ibuprofen for Acute Treatment of Episodic Tension-type Headache in Adults. Non-Steroidal Anti-Inflammatory Medicines (NSAIDs). Ibuprofen with or without an antiemetic for acute migraine headaches in adults. Ibuprofen With or Without an Antiemetic for Acute Migraine Headaches in Adults. Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) for Acute Migraine Treatment.
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